Appendix C: Substances requiring special approval

 

Attention: New drug enforcement administration requirements control the manufacture, distribution, export and import of certain chemicals. As of March 18, 1989, the following chemicals and their salts, isomers, and salts of optical isomers in threshold amounts, are subject to Federal Requirements under the Chemical Diversion and Trafficking Act of 1988. By your purchase you may be subject to record-keeping and reporting requirements of Federal Law. If you are not aware of this law, you should contact your local Drug Enforcement Administration office.

PRECURSOR CHEMICALS ESSENTIAL CHEMICALS

N-Acetylanthranilic acid Acetic anhydride
Anthranilic acid Acetone
Benzyl cyanide Benzyl chloride
Ephedrine 2-Butanone
Ergonovine Ethyl ether
Ergotamine Hydriodic acid
3,4-Methylenediozyphenyl-2-propanone Mehtyl Ethyl Ketone (MEK)
Norpseudoephedrine Potassium permanganate
Phenylacetic acid Toluene
Phenylpropanolamine
Piperidine
Pseudoephedrine
Benzaldehyde


The law also requires that certain records be kept regarding the distribution, export, and import of a tableting or encapsulating machine. The following list is of the different classifications of DEA Regulated Substances:

SCHEDULES OF CONTROLLED SUBSTANCES

Schedule I.

(1) Acetyl-alpha-methylfentanyl(N-[1-(1-methyl-2-phenethyl)-4-piperidinyl]-N-phenylacetamide)
(2) Acetylmethadol
(3) Allylprodine
(4) Alphacetylmethadol (except levo-alphacetylmethadol also known as levo-alpha-acetylmethadol, levomethadyl acetate, or LAAM)
(5) Alphameprodine
(6) Alphamethadol
(7) Alpha-methylfentanyl (N-[1-(alpha-methyl-beta-phenyl)ethyl-4-
piperidyl] propionanilide; 1-(1-methyl-2-phenylethyl)-4-(N-
propanilido) piperidine)
(8)Alpha-methylthiofentanyl(N-[1-methyl-2-(2-thienyl)ethyl-4-piperidinyl]-N-phenylpropanamide)
(9) Benzethidine
(10) Betacetylmethadol
(11) Beta-hydroxyfentanyl (N-[1-(2-hydroxy-2-phenethyl)-4- piperidinyl]-N-phenylpropanamide)
(12) Beta-hydroxy-3-methylfentanyl (other name: N-[1-(2-hydroxy-2-
phenethyl)-3-methyl-4-piperidinyl]-N-phenylpropanamide
(13) Betameprodine
(14) Betamethadol
(15) Betaprodine
(16) Clonitazene
(17) Dextromoramide
(18) Diampromide
(19) Diethylthiambutene
(20) Difenoxin
(21) Dimenoxadol
(22) Dimepheptanol
(23) Dimethylthiambutene
(24) Dioxaphetyl butyrate
(25) Dipipanone
(26) Ethylmethylthiambutene
(27) Etonitazene
(28) Etoxeridine
(29) Furethidine
(30) Hydroxypethidine
(31) Ketobemidone
(32) Levomoramide
(33) Levophenacylmorphan
(34) 3-Methylfentanyl (N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]- N-phenylpropanamide)
(35) 3-methylthiofentanyl (N-[(3-methyl-1-(2-thienyl)ethyl-4- piperidinyl]-N-phenylpropanamide)
(36) Morpheridine
(37) MPPP (1-methyl-4-phenyl-4-propionoxypiperidine)
(38) Noracymethadol
(39) Norlevorphanol
(40) Normethadone
(41) Norpipanone
(42) Para-fluorofentanyl (N-(4-fluorophenyl)-N-[1-(2-phenethyl)-4- piperidinyl] propanamide
(43) PEPAP (1-(-2-phenethyl)-4-phenyl-4-acetoxypiperidine
(44) Phenadoxone
(45) Phenampromide
(46) Phenomorphan
(47) Phenoperidine
(48) Piritramide
(49) Proheptazine
(50) Properidine
(51) Propiram
(52) Racemoramide
(53) Thiofentanyl (N-phenyl-N-[1-(2-thienyl)ethyl-4-piperidinyl]- propanamide
(54) Tilidine
(55) Trimeperidine

Opium derivatives:
(1) Acetorphine
(2) Acetyldihydrocodeine
(3) Benzylmorphine
(4) Codeine methylbromide
(5) Codeine-N-Oxide
(6) Cyprenorphine
(7) Desomorphine
(8) Dihydromorphine
(9) Drotebanol
(10) Etorphine (except hydrochloride salt)
(11) Heroin
(12) Hydromorphinol
(13) Methyldesorphine
(14) Methyldihydromorphine
(15) Morphine methylbromide
(16) Morphine methylsulfonate
(17) Morphine-N-Oxide
(18) Myrophine
(19) Nicocodeine
(20) Nicomorphine
(21) Normorphine
(22) Pholcodine
(23) Thebacon

Hallucinogenic substances:
(1) Alpha-ethyltryptamine
Some trade or other names: etryptamine; Monase; <greek-a>-ethyl-
1H-indole-3-ethanamine; 3-(2-aminobutyl) indole; <greek-a>-ET; and AET.
(2) 4-bromo-2,5-dimethoxy-amphetamine
Some trade or other names: 4-bromo-2,5-dimethoxy-<greek-a>-methylphenethylamine; 4-bromo-2,5-DMA
(3) 4-Bromo-2,5-dimethoxyphenethylamine
Some trade or other names: 2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane; alpha-desmethyl DOB; 2C-B, Nexus.
(4) 2,5-dimethoxyamphetamine
Some trade or other names: 2,5-dimethoxy-<greek-a>-methylphenethylamine; 2,5-DMA
(5) 2,5-dimethoxy-4-ethylamphet-amine
Some trade or other names: DOET
(6) 4-methoxyamphetamine
Some trade or other names: 4-methoxy-<greek-a>-methylphenethylamine; paramethoxyamphetamine, PMA
(7) 5-methoxy-3,4-mdthylenedioxy-amphetamine
(8) 4-methyl-2,5-dimethoxy-amphetamine
Some trade and other names: 4-methyl-2,5-dimethoxy-<greek-a>-methylphenethylamine; ``DOM''; and ``STP''
(9) 3,4-methylenedioxy amphetamine
(10) 3,4-methylenedioxymethamphetamine (MDMA)
(11) 3,4-methylenedioxy-N-ethylamphetamine (also known as) N-ethyl-
alpha-methyl-3,4(methylenedioxy)phenethylamine, N-ethyl MDA, MDE, MDEA
(12) N-hydroxy-3,4-methylenedioxyamphetamine (also known as N-
hydroxy-alpha-methyl-3,4(methylenedioxy)phenethylamine, and N-hydroxy MDA
(13) 3,4,5-trimethoxy amphetamine
(14) Bufotenine
Some trade and other names: 3-(<greek-b>-Dimethylaminoethyl)-5-hydroxyindole;3-(2-dimethylaminoethyl)-5-indolol; N, N-dimethylserotonin; 5-hydroxy-N,N-dimethyltryptamine; mappine
(15) Diethyltryptamine
Some trade and other names: N,N-Diethyltryptamine; DET
(16) Dimethyltryptamine
Some trade or other names: DMT
(17) Ibogaine
Some trade and other names: 7-Ethyl-6,6<greek-b>,7,8,9,10,12,13-
octahydro-2-methoxy-6,9-methano-5H-pyrido [1', 2':1,2] azepino[5,4-b] indole; Tabernantheiboga
(18) Lysergic acid diethylamide
(19) Marihuana
(20) Mescaline
(21) Parahexyl--7374; some trade or other names: 3-Hexyl-1-
hydroxy-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran; Synhexyl.
(22) Peyote: Meaning all parts of the plant presently classified botanically as Lophophora williamsii Lemaire, whether growing or not, the seeds thereof, any extract from any part of such plant, and every compound, manufacture, salts, derivative, mixture, or preparation of such plant, its seeds or extracts (Interprets 21 USC 812(c), Schedule I(c) (12))
(23) N-ethyl-3-piperidyl benzilate
(24) N-methyl-3-piperidyl benzilate
(25) Psilocybin
(26) Psilocyn
(27) Tetrahydrocannabinols: Synthetic equivalents of the substances contained in the plant, or in the resinous extractives of Cannabis, sp. and/or synthetic substances, derivatives, and their isomers with similar chemical structure and pharmacological activity such as the following: <greek-D>1 cis or trans tetrahydrocannabinol, and their optical isomers <greek-D>6 cis or trans tetrahydrocannabinol, and their optical isomers <greek-D>3,4 cis or trans tetrahydrocannabinol, and its optical isomers (Since nomenclature of these substances is not internationally standardized, compounds of these structures, regardless of numerical designation of atomic positions covered.)
28) Ethylamine analog of phencyclidine
Some trade or other names: N-ethyl-1-phenylcyclohexylamine, (1-
phenylcyclohexyl)ethylamine, N-(1-phenylcyclohexyl)ethylamine, cyclohexamine, PCE
(29) Pyrrolidine analog of phencyclidine
Some trade or other names: 1-(1-phenylcyclohexyl)-pyrrolidine, PCPy, PHP
(30) Thiophene analog of phencyclidine
Some trade or other names: 1-[1-(2-thienyl)-cyclohexyl]-piperidine, 2-thienylanalog of phencyclidine, TPCP, TCP
(31) 1-[1-(2-thienyl)cyclohexyl]pyrrolidine
Some other names: TCPy

Depressants:
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:

(1) Mecloqualone
(2) Methaqualone

Stimulants:
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers, and
salts of isomers:

(1) Aminorex (Some other names: aminoxaphen; 2-amino-5-phenyl-2-oxazoline; or 4,5-dihydro-5-phenly-2-oxazolamine)
(2) Cathinone
Some trade or other names: 2-amino-1-phenyl-1-propanone, alpha-
aminopropiophenone, 2-aminopropiophenone, and norephedrone
(3) Fenethylline
(4) Methcathinone (Some other names: 2-(methylamino)-propiophenone; alpha-(methylamino)propiophenone; 2-(methylamino)-1-phenylpropan-1-one; alpha-N-methylaminopropiophenone; monomethylpropion; ephedrone; N-methylcathinone; methylcathinone; AL-464; AL-422; AL-463 and UR1432), its salts, optical isomers and salts of optical isomers
(5) (<plus-minus>)cis-4-methylaminorex ((<plus-minus>)cis-4,5-
dihydro-4-methyl-5-phenyl-2-oxazolamine)
(6) N-ethylamphetamine
(7) N,N-dimethylamphetamine (also known as N,N-alpha-trimethyl-
benzeneethanamine; N,N-alpha-trimethylphenethylamine)

Temporary listing of substances subject to emergency scheduling. Any material, compound, mixture or preparation which contains any quantity of the following substances:
(1) N-[1-benzyl-4-piperidyl] -N- phenylpropanamide (benzylfentanyl), its optical isomers, salts and salts of isomers
(2) N-[1-(2-thienyl)methyl-4-piperidyl] -N- phenylpropanamide (thenylfentanyl), its optical isolers, salts and salts of isomers


Schedule II.

(1) Raw opium
(2) Opium extracts
(3) Opium fluid
(4) Powdered opium
(5) Granulated opium
(6) Tincture of opium
(7) Codeine
(8) Ethylmorphine
(9) Etorphine hydrochloride
(10) Hydrocodone
(11) Hydromorphone
(12) Metopon
(13) Morphine
(14) Oxycodone
(15) Oxymorphone
(16) Thebaine

Opium poppy and poppy straw.

Coca leaves (9040) and any salt, compound, derivative or preparation of coca leaves (including cocaine (9041) and ecgonine (9180) and their salts, isomers, derivatives and salts of isomers and derivatives), and any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of these substances, except that the substances shall not include decocainized coca leaves or extraction of coca leaves, whhch extractions do not contain cocaine or ecgonine.

Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy), 9670.

Opiates. Unless specifically excepted or unless in another schedule any of the following opiates, including its isomers, esters, ethers, salts and salts of isomers, esters and ethers whenever the
existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation, dextrorphan and levopropoxyphene excepted:
(1) Alfentanil
(2) Alphaprodine
(3) Anileridine
(4) Bezitramide
(5) Bulk dextropropoxyphene (non-dosage forms)
(6) Carfentanil
(7) Dihydrocodeine
(8) Diphenoxylate
(9) Fentanyl
(10) Isomethadone
(11) Levo-alphacetylmethadol
[Some other names: levo-alpha-acetylmethadol, levomethadyl acetate, LAAM]
(12) Levomethorphan
(13) Levorphanol
(14) Metazocine
(15) Methadone
(16) Methadone-Intermediate, 4-cyano-2-dimethylamino-4,4-diphenyl butane
(17) Moramide-Intermediate, 2-methyl-3-morpholino-1, 1-diphenylpropane-carboxylic acid
(18) Pethidine (meperidine)
(19) Pethidine-Intermediate-A, 4-cyano-1-methyl-4-phenylpiperidine
(20) Pethidine-Intermediate-B, ethyl-4-phenylpiperidine-4-carboxylate
(21) Pethidine-Intermediate-C, 1-methyl-4-phenylpiperidine-4-carboxylic acid
(22) Phenazocine
(23) Piminodine
(24) Racemethorphan
(25) Racemorphan
(26) Remifentanil
(27) Sufentanil

Stimulants:
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system:

(1) Amphetamine, its salts, optical isomers, and salts of its optical isomers
(2) Methamphetamine, its salts, isomers, and salts of its isomers
(3) Phenmetrazine and its salts
(4) Methylphenidate

Depressants:
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
(1) Amobarbital
(2) Glutethimide
(3) Pentobarbital
(4) Phencyclidine
(5) Secobarbital

Hallucinogenic substances:
(1) Dronabinol (synthetic) in sesame oil and encapsulated in a soft gelatin capsule in a U.S. Food and Drug Administration approved drug product. [Some other names for dronabinol: (6aR-trans)-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol, or (-)-delta-9-(trans)-tetrahydrocannabinol]
(2) Nabilone [Another name for nabilone: (<plus-minus>) -trans-3-(1,1- dimethylheptyl) -6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one]

Immediate precursors:
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances:
(1) Immediate precursor to amphetamine and methamphetamine:
(i) Phenylacetone - Some trade or other names: phenyl-2-propanone; P2P; benzyl methyl ketone; methyl benzyl ketone;
(2) Immediate precursors to phencyclidine (PCP):
(i) 1-phenylcyclohexylamine
(ii) 1-piperidinocyclohexanecarbonitrile (PCC)




Schedule III.

(1) Those compounds, mixtures, or preparations in dosage unit form containing any stimulant substances listed in schedule II which compounds, mixtures, or preparations were listed on August 25, 1971, as excepted compounds under Sec. 1308.32, and any other drug of the quantitative composition shown in that list for those drugs or which is the same except that it contains a lesser quantity of controlled substances.

(2) Benzphetamine
(3) Chlorphentermine
(4) Clortermine
(5) Phendimetrazine

Depressants:
(1) Any compound, mixture or preparation containing:
(i) Amobarbital
(ii) Secobarbital
(iii) Pentobarbital
or any salt thereof and one or more other active medicinal ingredients which are not listed in any schedule.
(2) Any suppository dosage form containing:
(i) Amobarbital
(ii) Secobarbital
(iii) Pentobarbital
or any salt of any of these drugs and approved by the Food and Drug Administration for marketing only as a suppository.
(3) Any substance which contains any quantity of a derivative of barbituric acid or any salt thereof
(4) Chlorhexadol
(5) Lysergic acid
(6) Lysergic acid amide
(7) Methyprylon
(8) Sulfondiethylmethane
(9) Sulfonethylmethane
(10) Sulfonmethane
(11) Tiletamine and zolazepam or any salt thereof
Some trade or other names for a tiletamine-zolazepam combination product: Telazol
Some trade or other names for tiletamine: 2-(ethylamino)-2-(2-thienyl)-cyclohexanone
Some trade or other names for zolazepam: 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo-[3,4-e] [1,4]-diazepin-7(1H)-one, flupyrazapon

Nalorphine 9400

Narcotic Drugs

Anabolic steroids



Schedule IV.

(1) Alprazolam
(2) Barbital
(3) Bromazepam
(4) Camazepam
(5) Chloral betaine
(6) Chloral hydrate
(7) Chlordiazepoxide
(8) Clobazam
(9) Clonazepam
(10) Clorazepate
(11) Clotiazepam
(12) Cloxazolam
(13) Delorazepam
(14) Diazepam
(15) Estazolam
(16) Ethchlorvynol
(17) Ethinamate
(18) Ethyl loflazepate
(19) Fludiazepam
(20) Flunitrazepam
(21) Flurazepam
(22) Halazepam
(23) Haloxazolam
(24) Ketazolam
(25) Loprazolam
(26) Lorazepam
(27) Lormetazepam
(28) Mebutamate
(29) Medazepam
(30) Meprobamate
(31) Methohexital (Brevital sodium)
(32) Methylphenobarbital (mephobarbital)
(33) Midazolam
(34) Nimetazepam
(35) Nitrazepam
(36) Nordiazepam
(37) Oxazepam
(38) Oxazolam
(39) Paraldehyde
(40) Petrichloral
(41) Phenobarbital
(42) Pinazepam
(43) Prazepam
(44) Quazepam
(45) Temazepam
(46) Tetrazepam
(47) Triazolam
(48) Zolpidem

Fenfluramine: Any material, compound, mixture, or preparation which contains any quantity of, Fenfluramine, including its salts, isomers (whether optical, position, or geometric), and salts of such isomers, whenever the existence of such salts, isomers, and salts of isomers is possible
Stimulants: Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers and salts of isomers:
(1) Cathine ((+)-norpseudoephedrine)
(2) Diethylpropion
(3) Fencamfamin
(4) Fenproporex
(5) Mazindol
(6) Mefenorex
(7) Pemoline (including organometallic complexes and chelates thereof)
(8) Phentermine
(9) Pipradrol
(10) SPA ((-)-1-dimethylamino-1,2-diphenylethane)

Pentazocine.


Schedule V.

Buprenorphine

Pyrovalerone