THIRTEEN OSHA-REGULATED CARCINOGENS:

Attention: NIOSH has identified numerous substances that should be treated as potential occupational carcinogens even though OSHA may not have identified them as such. In determining their carcinogenicity, NIOSH uses the OSHA classification outlined in 29 CFR 1990.103. If the material you are using is listed in the above table, or is identified as a potential carcinogen on the MSDS, the precautions discussed in section XI.A should be followed.

EXAMPLES OF REPRODUCTIVE TOXINS:

CHEMICALS THAT ARE HIGHLY TOXIC:

CAS No. Chemical name

75-86-5 Acetone Cyanohydrin
1752-30-3 Acetone Thiosemicarbazide
107-02-8 Acrolein
79-06-1 Acrylamide
107-13-1 Acrylonitrile
814-68-6 Acrylyl Chloride
111-69-3 Adiponitrile
116-06-3 Aldicarb
309-00-2 Aldrin
107-18-6 Allyl Alcohol
107-11-9 Allylamine
20859-73-8 Aluminum Phosphide
54-62-6 Aminopterin
78-53-5 Amiton
3734-97-2 Amiton Oxalate
7664-41-7 Ammonia
300-62-9 Amphetamine
62-53-3 Aniline
88-05-1 Aniline, 2,4,6-Trimethyl-
7783-70-2 Antimony Pentafluoride
1397-94-0 Antimycin A
86-88-4 ANTU
1303-28-2 Arsenic Pentoxide
1327-53-3 Arsenous Oxide
7784-34-1 Arsenous Trichloride
7784-42-1 Arsine
2642-71-9 Azinphos-Ethyl
86-50-0 Azinphos-Methyl
98-87-3 Benzal Chloride
98-16-8 Benzenamine, 3-(Trifluoromethyl)-
100-14-1 Benzene, 1-(Chloromethyl)-4-Nitro-
98-05-5 Benzenearsonic Acid
3615-21-2 Benzimidazole, 4, 5- Dichloro-2-(Trifluoromethyl)-
98-07-7 Benzotrichloride
100-44-7 Benzyl Chloride
140-29-4 Benzyl Cyanide
15271-41-7 Bicyclo[2.2.1]Heptane-2-Carbonitrile, 5-Chloro-6-((((Methylamino)Carbonyl)Oxy)Imino)-, (1s-(1-alpha, 2-beta, 4-alpha, 5-alpha,6E))-
534-07-6 Bis(Chloromethyl) Ketone
4044-65-9 Bitoscanate
10294-34-5 Boron Trichloride
7637-07-2 Boron Trifluoride
353-42-4 Boron Trifluoride Compound With Methyl Ether (1:1)
28772-56-7 Bromadiolone
7726-95-6 Bromine
1306-19-0 Cadmium Oxide
2223-93-0 Cadmium Stearate
7778-44-1 Calcium Arsenate
8001-35-2 Camphechlor
56-25-7 Cantharidin
51-83-2 Carbachol Chloride
26419-73-8 Carbamic Acid, Methyl-, O-(((2,4-Dimethyl-1, 3-Dithiolan-2-yl)Methylene)Amino)-
1563-66-2 Carbofuran
75-15-0 Carbon Disulfide
786-19-6 Carbophenothion
57-74-9 Chlordane
470-90-6 Chlorfenvinfos
7782-50-5 Chlorine
24934-91-6 Chlormephos
999-81-5 Chlormequat Chloride
79-11-8 Chloroacetic Acid
107-07-3 Chloroethanol
627-11-2 Chloroethyl Chloroformate
67-66-3 Chloroform
542-88-1 Chloromethyl Ether
107-30-2 Chloromethyl Methyl Ether
3691-35-8 Chlorophacinone
1982-47-4 Chloroxuron
21923-23-9 Chlorthiophos
10025-73-7 Chromic Chloride
62207-76-5 Cobalt, ((2,2'-(1,2-Ethanediylbis (Nitrilomethylidyne)) Bis(6-Fluorophenolato)) (2-)-N,N',O,O')-
10210-68-1 Cobalt Carbonyl
64-86-8 Colchicine
56-72-4 Coumaphos
5836-29-3 Coumatetralyl
95-48-7 Cresol, o-
535-89-7 Crimidine
4170-30-3 Crotonaldehyde
123-73-9 Crotonaldehyde, (E)-
506-68-3 Cyanogen Bromide
506-78-5 Cyanogen Iodide
2636-26-2 Cyanophos
675-14-9 Cyanuric Fluoride
66-81-9 Cycloheximide
108-91-8 Cyclohexylamine
17702-41-9 Decaborane(14)
8065-48-3 Demeton
919-86-8 Demeton-S-Methyl
10311-84-9 Dialifor
19287-45-7 Diborane
111-44-4 Dichloroethyl ether
149-74-6 Dichloromethylphenylsilane
62-73-7 Dichlorvos
141-66-2 Dicrotophos
1464-53-5 Diepoxybutane
814-49-3 Diethyl Chlorophosphate
71-63-6 Digitoxin
2238-07-5 Diglycidyl Ether
20830-75-5 Digoxin
115-26-4 Dimefox
60-51-5 Dimethoate
2524-03-0 Dimethyl Phosphorochloridothioate
77-78-1 Dimethyl sulfate
75-78-5 Dimethyldichlorosilane
57-14-7 Dimethylhydrazine
99-98-9 Dimethyl-p-Phenylenediamine
644-64-4 Dimetilan
534-52-1 Dinitrocresol
88-85-7 Dinoseb
1420-07-1 Dinoterb
78-34-2 Dioxathion
82-66-6 Diphacinone
152-16-9 Diphosphoramide, Octamethyl-
298-04-4 Disulfoton
514-73-8 Dithiazanine Iodide
541-53-7 Dithiobiuret
316-42-7 Emetine, Dihydrochloride
115-29-7 Endosulfan
2778-04-3 Endothion
72-20-8 Endrin
106-89-8 Epichlorohydrin
2104-64-5 EPN
50-14-6 Ergocalciferol
379-79-3 Ergotamine Tartrate
1622-32-8 Ethanesulfonyl Chloride, 2-Chloro-
10140-87-1 Ethanol, 1,2-Dichloro-, Acetate
563-12-2 Ethion
13194-48-4 Ethoprophos
538-07-8 Ethylbis(2-Chloroethyl)Amine
371-62-0 Ethylene Fluorohydrin
75-21-8 Ethylene Oxide
107-15-3 Ethylenediamine
151-56-4 Ethyleneimine
542-90-5 Ethylthiocyanate
22224-92-6 Fenamiphos
115-90-2 Fensulfothion
4301-50-2 Fluenetil
7782-41-4 Fluorine
640-19-7 Fluoroacetamide
144-49-0 Fluoroacetic Acid
359-06-8 Fluoroacetyl Chloride
51-21-8 Fluorouracil
944-22-9 Fonofos
50-00-0 Formaldehyde
107-16-4 Formaldehyde Cyanohydrin
23422-53-9 Formetanate Hydrochloride
2540-82-1 Formothion
17702-57-7 Formparanate
21548-32-3 Fosthietan
3878-19-1 Fuberidazole
110-00-9 Furan
13450-90-3 Gallium Trichloride
77-47-4 Hexachlorocyclopentadiene
4835-11-4 Hexamethylenediamine, N,N'-Dibutyl-
302-01-2 Hydrazine
74-90-8 Hydrocyanic Acid
7647-01-0 Hydrogen Chloride (gas only)
7664-39-3 Hydrogen Fluoride
7722-84-1 Hydrogen Peroxide (Conc > 52%)
7783-07-5H Hydrogen Selenide
7783-06-4 Hydrogen Sulfide
123-31-9 Hydroquinone
13463-40-6 Iron, Pentacarbonyl-
297-78-9 Isobenzan
78-82-0 Isobutyronitrile
102-36-3 Isocyanic Acid, 3,4-Dichlorophenyl Ester
465-73-6 Isodrin
55-91-4 Isofluorphate
4098-71-9 Isophorone Diisocyanate
108-23-6 Isopropyl Chloroformate
119-38-0 Isopropylmethylpyrazolyl Dimethylcarbamate
78-97-7 Lactonitrile
21609-90-5 Leptophos
541-25-3 Lewisite
58-89-9 Lindane
7580-67-8 Lithium Hydride
109-77-3 Malononitrile
12108-13-3 Manganese,Tricarbonyl Methylcyclopentadienyl
51-75-2 Mechlorethamine
950-10-7 Mephosfolan
1600-27-7 Mercuric Acetate
7487-94-7 Mercuric Chloride
21908-53-2 Mercuric Oxide
10476-95-6 Methacrolein Diacetate
760-93-0 Methacrylic Anhydride
126-98-7 Methacrylonitrile
920-46-7 Methacryloyl Chloride
30674-80-7 Methacryloyloxyethyl Isocyanate
10265-92-6 Methamidophos
558-25-8 Methanesulfonyl Fluoride
950-37-8 Methidathion
2032-65-7 Methiocarb
16752-77-5 Methomyl
151-38-2 Methoxyethylmercuric Acetate
80-63-7 Methyl 2-Chloroacrylate
74-83-9 Methyl Bromide
79-22-1 Methyl Chloroformate
60-34-4 Methyl Hydrazine
624-83-9 Methyl Isocyanate
556-61-6 Methyl Isothiocyanate
74-93-1 Methyl Mercaptan
3735-23-7 Methyl Phenkapton
676-97-1 Methyl Phosphonic Dichloride
556-64-9 Methyl Thiocyanate
78-94-4 Methyl Vinyl Ketone
502-39-6 Methylmercuric Dicyanamide
75-79-6 Methyltrichlorosilane
1129-41-5 Metolcarb
7786-34-7 Mevinphos
315-18-4 Mexacarbate
50-07-7 Mitomycin C
6923-22-4 Monocrotophos
2763-96-4 Muscimol
505-60-2 Mustard Gas
13463-39-3 Nickel Carbonyl
54-11-5 Nicotine
65-30-5 Nicotine Sulfate
7697-37-2 Nitric Acid
10102-43-9 Nitric Oxide
98-95-3 Nitrobenzene
1122-60-7 Nitrocyclohexane
10102-44-0 Nitrogen Dioxide
62-75-9 Nitrosodimethylamine
991-42-4 Norbormide
0 Organorhodium Complex (PMN-82-147).
630-60-4 Ouabain
23135-22-0 Oxamyl
78-71-7 Oxetane, 3,3-Bis(Chloromethyl)-
2497-07-6 Oxydisulfoton
10028-15-6 Ozone
1910-42-5 Paraquat Dichloride
2074-50-2 Paraquat Methosulfate
56-38-2 Parathion
298-00-0 Parathion-Methyl
12002-03-8 Paris Green
19624-22-7 Pentaborane
2570-26-5 Pentadecylamine
79-21-0 Peracetic Acid
594-42-3 Perchloromethylmercaptan
108-95-2 Phenol
4418-66-0 Phenol, 2,2'-Thiobis(4-Chloro6-Methyl)-
64-00-6 Phenol, 3-(1-Methylethyl)-, Methylcarbamate
58-36-6 Phenoxarsine, 10,10'-Oxydi-
696-28-6 Phenyl Dichloroarsine
59-88-1 Phenylhydrazine Hydrochloride
62-38-4 Phenylmercury Acetate
2097-19-0 Phenylsilatrane
103-85-5 Phenylthiourea
298-02-2 Phorate
4104-14-7 Phosacetim
947-02-4 Phosfolan
75-44-5 Phosgene
732-11-6 Phosmet
13171-21-6 Phosphamidon
7803-51-2 Phosphine
2703-13-1 Phosphonothioic Acid, Methyl-, O-Ethyl O-(4- (Methylthio) Phenyl) Ester
50782-69-9 Phosphonothioic Acid, Methyl-, S-(2-(Bis(1Methylethyl)Amino)Ethyl) O-Ethyl Ester
2665-30-7 Phosphonothioic Acid, Methyl-, O-(4-Nitrophenyl) O-Phenyl Ester
3254-63-5 Phosphoric Acid, Dimethyl 4-(Methylthio)Pheny l Ester
2587-90-8 Phosphorothioic Acid, O,O-Dimethyl-S-(2-Methylthio) Ethyl Ester
7723-14-0 Phosphorus
10025-87-3 Phosphorus Oxychloride
10026-13-8 Phosphorus Pentachloride
7719-12-2 Phosphorus Trichloride
57-47-6 Physostigmine
57-64-7 Physostigmine, Salicylate (1:1)
124-87-8 Picrotoxin
110-89-4 Piperidine
23505-41-1 Pirimifos-Ethyl
10124-50-2 Potassium Arsenite
151-50-8 Potassium Cyanide
506-61-6 Potassium Silver Cyanide
2631-37-0 Promecarb
106-96-7 Propargyl Bromide
57-57-8 Propiolactone, Beta-
107-12-0 Propionitrile
542-76-7 Propionitrile, 3-Chloro-
70-69-9 Propiophenone, 4-Amino-
109-61-5 Propyl Chloroformate
75-56-9 Propylene Oxide
75-55-8 Propyleneimine
2275-18-5 Prothoate
129-00-0 Pyrene
140-76-1 Pyridine, 2-Methyl-5-Vinyl-
504-24-5 Pyridine, 4-Amino-
1124-33-0 Pyridine, 4-Nitro-,l-Oxide
53558-25-1 Pyriminil
14167-18-1 Salcomine
107-44-8 Sarin
7783-00-8 Selenious Acid
7791-23-3 Selenium Oxychloride
563-41-7 Semicarbazide Hydrochloride
3037-72-7 Silane, (4-Aminobutyl) Diethosymethyl-
7631-89-2 Sodium Arsenate
7784-46-5 Sodium Arsenite
26628-22-8 Sodium Azide (Na(N<INF>3))
124-65-2 Sodium Cacodylate
143-33-9 Sodium Cyanide (Na(CN))
62-74-8 Sodium Fluoroacetate
13410-01-0 Sodium Selenate
10102-18-8 Sodium Selenite
10102-20-2 Sodium Tellurite
900-95-8 Stannane, Acetoxytriphenyl-
57-24-9 Strychnine
60-41-3 Strychnine Sulfate
3689-24-5 Sulfotep
3569-57-1 Sulfoxide, 3-Chloropropyl Octyl
7446-09-5 Sulfur Dioxide
7783-60-0 Sulfur Tetrafluoride
7446-11-9 Sulfur Trioxide
7664-93-9 Sulfuric Acid
77-81-6 Tabun
7783-80-4 Tellurium Hexafluoride
107-49-3 TEPP
13071-79-9 Terbufos
78-00-2 Tetraethyllead
597-64-8 Tetraethyltin
75-74-1 Tetramethyllead
509-14-8 Tetranitromethane
10031-59-1 Thallium Sulfate
6533-73-9 Thallous Carbonate
7791-12-0 Thallous Chloride
2757-18-8 Thallous Malonate
7446-18-6 Thallous Sulfate
2231-57-4 Thiocarbazide
39196-18-4 Thiofanox
297-97-2 Thionazin
108-98-5 Thiophenol
79-19-6 Thiosemicarbazide
5344-82-1 Thiourea, (2-Chlorophenyl)-
614-78-8 Thiourea, (2-Methylphenyl)-
7550-45-0 Titanium Tetrachloride
584-84-9 Toluene 2,4-Diisocyanate
91-08-7 Toluene 2,6-Diisocyanate
110-57-6 Trans-1,4-Dichlorobutene
1031-47-6 Triamiphos
24017-47-8 Triazofos
76-02-8 Trichloroacetyl Chloride
115-21-9 Trichloroethylsilane
327-98-0 Trichloronate
98-13-5 Trichlorophenylsilane
1558-25-4 Trichloro(Chloromethyl) Silane
27137-85-5 Trichloro(Dichlorophenyl) Silane
998-30-1 Triethoxysilane
75-77-4 Trimethylchlorosilane
824-11-3 Trimethylolpropane Phosphite
1066-45-1 Trimethyltin Chloride
639-58-7 Triphenyltin Chloride
555-77-1 Tris(2-Chloroethyl)Amine
2001-95-8 Valinomycin
1314-62-1 Vanadium Pentoxide
108-05-4 Vinyl Acetate Monomer
81-81-2 Warfarin
129-06-6 Warfarin Sodium
28347-13-9 Xylylene Dichloride
58270-08-9 Zinc,Dichloro(4,4-Dimethyl5((((Methylamino)Carbonyl)Oxy)Imino)Pentae nitrile)-, (T-4)-
1314-84-7 Zinc Phosphide

BIOLOGICALLY ACTIVE COMPOUNDS:

A. Severe Peroxide Hazard with Exposure to Air

(discard within 3 months from opening)

Diisopropyl ether (isopropyl ether)
Divinylacetylene (DVA)
Vinylidene chloride (1,1-dichloroethylene)
Potassium metal
Sodium amide (sodamide)
Potassium amide

B. Peroxide Hazard on Concentration

Do not distill/evaporate without first testing for the presence of peroxides (discard/test for peroxides after 6 months)

acetaldehyde diethyl acetal (acetal)
ethylene glycol dimethyl ether (glyme)
cumene (isopropylbenzene)
ethylene glycol ether acetates
cyclohexene ethylene glycol monoethers (cellosolves)
cyclopentene furan
decalin (decahydronaphthalene)
methylacetylene
diacetylene (butadiene)
methylcyclopentane
dicyclopentadiene
methyl isobutyl ketone
diethyl ether (ether)
tetrahydrofuran (THF)
diethylene glycol dimethyl ether (diglyme)
tetralin (tetrahydronaphthalene)
dioxane vinyl ethers

C. Hazard of Rapid Polymerization Initiated by Internally-FormedPeroxides

Liquids: (discard or test for peroxides after 6 months)

chloroprene (2-chloro-1,3-butadiene)
vinyl acetate
styrene
vinylpyridine

Gases: (discard after 12 months)

butadiene
vinylacetylene (MVA)
tetrafluoroethylene (TFE)
vinyl chloride

POISONOUS GASES:

Arsine Nitrogen trioxide
Boron trichloride Nitrosyl chloride
Chlorine pentafluoride Oxygen difluoride
Chlorine trifluoride Phosgene
Cyanogen Phosphine
Cyanogen chloride Phosphorus pentafluoride
Diborane Selenium hexafluoride
Dinitrogen tetroxide Stibine
Fluorine Sulfur tetrafluoride
Germane Tellurium Hexafluoride
Hydrogen selenide Tetraethyldithiopyrophosphate
Nitric oxide Tetraethylpyrophosphate
Nitrogen dioxide

Attention: Departments may choose to add other chemicals to the above list: for example, sulfur-containing compounds such as a mercaptans can cause significant odor problems when used in the laboratory. Pre-approval of the conditions under which they can be used may prevent odor complaints.

SHOCK SENSITIVE CHEMICALS:

- Acetylenic compounds, especially polyacetylenes, haloacetylenes, and heavy metal salts of acetylenes (copper, silver, and mercury salts are particularly sensitive).
- Acyl nitrates
- Alkyl nitrates, particularly polyol nitrates such as nitrocellulose and nitroglycerine
- Alkyl and acyl nitrites
- Alkyl perchlorates
- Amminemetal oxosalts: metal compounds with coordinated ammonia, hydrazine, or similar nitrogenous donors and ionic perchlorate, nitrate, permanganate, or other oxidizing group.
- Azides, including metal, nonmetal, and organic azides
- Chlorite salts of metals, such as AgClO2 and Hg(ClO2)2
- Diazo compounds such as CH2N2
- Diazonium salts, when dry
- Fulminates such as mercury fulminate (Hg(CNO)2).
- Hydrogen peroxide (which becomes increasingly treacherous as the concentration rises above 0%, forming explosive mixtures with organic materials and decomposing violently in the presence of traces of transition metals.
- N-Halogen compounds such as difluoroamino compounds and halogen azides.
- N-Nitro compounds such as N-nitromethylamine, nitrourea, nitroguanidine, and nitric amide.
- Oxo salts of nitrogenous bases: perchlorates, dichromates, nitrates, iodates, chlorites, chlorates, and permanganates of ammonia, amines, hydroxylamine, guanidine, etc.
- Perchlorate salts (which can form when perchloric acid mists dry in fume hoods or associated duct work. Most metal, nonmetal, and amine perchlorates can be detonated and may undergo violent reaction in contact with combustible materials).
- Peroxides and hydroperoxides, organic
- Peroxides (solid) that crystallize from or are left from evaporation of peroxidizable solvents.
- Peroxides, transition-metal salts
- Picrates, especially salts of transition and heavy metals, such as Ni, Pb, Hg, Cu, and Zn
- Polynitroalkyl compounds such as tetranitromethane and dinitroacetonitrile.
- Polynitroaromatic compounds especially polynitrohydrocarbons, phenols, and amines (e.g., dinitrotoluene, trinitrotoluene, and picric acid).

PYROPHORIC CHEMICALS:

- Grignard reagents, RMgX
- Metal alkyls and aryls, such as RLi, RNa, R3Al, R2Zn
- Metal carbonyls such as Ni(CO)4, Fe(CO)5, Co2(CO)8
- Alkali metals such as Na, K
- Metal powders, such as Al, Co, Fe, Mg, Mn, Pd, Pt, Ti, Sn, Zn, Zr
- Metal hydrides such as NaH, LiAlH4
- Nonmetal hydrides, such as B2H6 and other boranes, PH3, AsH3
- Nonmetal alkyls, such as R3B, R3P, R3As
- Phosphorus (white)